CH 223191
CH 223191
CAS: 301326-22-7
Molecular Formula: C19H19N5O
CH 223191 - Names and Identifiers
CH 223191 - Physico-chemical Properties
| Molecular Formula | C19H19N5O |
| Molar Mass | 333.39 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Melting Point | >164°C (dec.) |
| Boling Point | 469.4±45.0 °C(Predicted) |
| Solubility | DMSO: ≥20mg/mL |
| Appearance | powder |
| Color | orange-brown |
| pKa | 12.98±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. |
| In vivo study | CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. |
CH 223191 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 22 - Do not breathe dust. |
| WGK Germany | 3 |
CH 223191 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.999 ml | 14.997 ml | 29.995 ml |
| 5 mM | 0.6 ml | 2.999 ml | 5.999 ml |
| 10 mM | 0.3 ml | 1.5 ml | 2.999 ml |
| 5 mM | 0.06 ml | 0.3 ml | 0.6 ml |
Last Update：2024-01-02 23:10:35
CH 223191 - Reference Information
| biological activity | CH-223191 is a potent antagonist of a specific aryl hydrocarbon receptor (AhR) with an IC50 of 30 nM. |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: CH 223191 Visit Supplier Webpage Request for quotationCAS: 301326-22-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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